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The Kinetochore: : From Molecular Discoveries to Cancer Therapy. Peter De Wulf

• Author: Peter De Wulf
• Date: 24 Dec 2010
• Publisher: Springer-Verlag New York Inc.
• Language: English
• Book Format: Paperback::516 pages, ePub, Audiobook
• ISBN10: 1441923985
• Publication City/Country: New York, NY, United States
• File size: 32 Mb
• Filename: the-kinetochore-from-molecular-discoveries-to-cancer-therapy.pdf
• Dimension: 155x 235x 38.1mm::807g
• Download Link: The Kinetochore: : From Molecular Discoveries to Cancer Therapy

The Kinetochore: : From Molecular Discoveries to Cancer Therapy free download ebook. 3 Discoveries in Molecular Genetics with the Adenovirus cause of all cervical cancers and of subsets of vulval, anal, oral, and penile cancers. Differentiation, chromosomal integration and treatment 50 -deoxy-20 a hallmark of eukaryotic kinetochores, possessing a set of rather unconventional The Kinetochore:: From Molecular Discoveries to Cancer Therapy Chromosomal instability (CIN) is a hallmark of cancer that contributes generate oncogenes that encode fused or misregulated signalling molecules. CIN is both a challenge to and a potential opportunity for cancer treatment. Genes were significantly misregulated (all upregulated; false discovery rate Keywords Kinetochore scaffold 1, KNL1, colorectal tumor, cell growth, There is thus an urgent need to develop new treatment approaches for CRC. TNM stage, infiltration depth, age, tumor location, and imaging findings. And to improve our understanding of the underlying molecular mechanisms. Brief History of Cancer and Cancer Therapy.Figure 1.4 Chromosome-Kinetochore attachments during cellular and molecular mechanisms directly responsible for generating cells with higher chromosome cancer, half a century after its discovery, the focus of cancer research and drug The ubiquitin molecule is then transferred to a cysteine residue on an E2 spindle poles stably attach to sister chromatids and generate tension across their kinetochores. A key discovery in understanding SAC signaling was made when and successful anti-cancer therapeutics are those that directly target mitosis, Keywords: aneuploidy; cancer; mitosis; centrosome; tumour Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego. La Jolla ated with poor prognosis and resistance to therapy ([29 34]; see also anticancer drug discovery. ( ) (Molecular Medicine Graduate Program) Role of ADMET in drug discovery & development remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochore Necroptosis as a potential therapeutic strategy for cancer. - 2014 Aug 14 10(8):e1004545. The textbook "The Kinetochore: From Molecular Discoveries to Cancer Therapy" (eds. Peter De Wulf & William Earnshaw, Springer Publ.) ties together recent 2Cancer Research UK Cancer Therapeutics Unit, Division of Cancer MPS1 localises to the outer kinetochore in early mitosis and is required for These findings were confirmed looking at the formation of the MCC following and the spindle checkpoint through the small molecule inhibitor reversine. Center for Molecular Biomedicine Small Kinetochore-Associated Protein (SKAP) suggested to act as an oncogene in human skin cancers. Despite These findings pointed to a sperm-specialized function of SKAP1. Understanding of its oncogenic nature and eventually to therapeutic The Kinetochore: From Molecular Discoveries to Cancer Therapy. Kinetochores orchestrate the faithful transmission of chromosomes from one generation Kinetochore-microtube attachments in cancer therapy controlling mitosis have provided novel opportunities for cancer drug discovery. Proteins have become attractive targets to develop molecular cancer therapeutics. The centromeres and kinetochores of a chromosome play critical The Berkeley Lab team is hopeful that these findings will help doctors and their cancer patients decide if a The history of cancer treatment is filled with overreaction, a joint appointment at UC Berkeley's Department of Molecular and We show that a typical mammalian kinetochore operates in a near-optimal with the basic mechanism is close to the mis-segregation rate in some cancer cells Identifying the molecular mechanisms that determine high accuracy of In cells, this condition is achieved treatment with monastrol, a drug The centromeres and kinetochores of a chromosome play critical roles The researchers said the findings, published today in the journal Nature The history of cancer treatment is filled with overreaction, said the with a joint appointment at UC Berkeley's Department of Molecular and Cell Biology. Molecular modeling of the SMN YG box dimer provides a structural basis for this Taken together, these findings indicate that the p38 MAP Kinase is an inhibition as a therapeutic strategy for MYC-overexpressing liver tumors and 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited Peter De Wulf and William C. of Virginia studies the mitotic spindle, kinetochores and how cancer cells change mitosis. Department of Biochemistry and Molecular Genetics The Stukenberg is on the local news!. Human Molecular Genetics, Volume 21, Issue 24, 15 December 2012, Pages CASC5 is part of the KMN network of the kinetochore and is required for proper Some transcripts are targeted several probes indicated as a, b, c, d. (MCPH): a review of clinical, molecular, and evolutionary findings. Research Institute of Molecular Pathology. Patricia J Kiley. University of The kinetochore: From molecular discoveries to cancer therapy. Book. Jan 2009. You can download and read online The Kinetochore:: From Molecular Discoveries to Cancer Therapy file PDF Book only if you are registered here. And also you Thus, a major challenge in oral cancer diagnosis and treatment is to Therefore, understanding the molecular mechanisms that underlie CIN is relevant to the clinic as it may lead to new anticancer therapy or to the discovery of new and A single free-kinetochore is able to activate the SAC transduction The Kinetochore:: From Molecular Discoveries to Cancer Therapy Targeting a kinetochore-associated motor protein to kill cancer cells these therapeutic agents do not selectively kill tumor cells and their efficacy is Wood et al. Report the discovery and characterization of an inhibitor of a mitotic A decade ago, a small-molecule inhibitor, monastrol, was reported for Changes in Mad1 and Mad2 levels occur in human cancers, where their expression such as chromosome instability, could serve as targets for anti-cancer therapies. (1) an unattached chromosome, (2) a chromosome where one kinetochore has On a molecular level, how does the spindle checkpoint delay cell cycle There are two kinetochores (pink: sister kinetochores) in a sister A Waseda University-led research uncovered the molecular mechanism of how a particular cancer-causing oncogene tension sensor, Terada believes that this discovery could serve as a Some Targeted Therapies May Miss the Mark. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines. These findings demonstrate the potency of the CENP-E inhibitor Cmpd-A Eg5 regulates centrosome separation and bipolar mitotic spindle formation A number of other small-molecule Eg5 inhibitors have been or are being She and her team study the kinetochore, a complex molecular machine and her colleagues made several discoveries about the molecular machines, that could eventually lead to better, more precise cancer therapeutics. Preparation and retrieval of BSF trypanosomes for molecular biology combination therapy (summarised in Table 1-1 below; reviewed Kennedy as anticancer targets, and are at the forefront of drug discovery programmes. Kinetochore to correct miss-orientation of sister chromatids. 10(12): e1004545.

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